The “socket directory” defaults either to $HOME/.screen or simply to /tmp/screens or preferably to /var/run/screen chosen at compile-time. If screen is installed setuid-root, then the administrator should compile screen with an adequate (not NFS mounted) socket directory. If screen is not running setuid-root, the user can specify any mode 700 directory in the environment variable $SCREENDIR.

When screen is invoked, it executes initialization commands from the files “/etc/screenrc” and “.screenrc” in the user's home directory. These are the “programmer's defaults” that can be overridden in the following ways: for the global screenrc file screen searches for the environment variable $SYSSCREENRC (this override feature may be disabled at compile-time). The user specific screenrc file is searched in $SCREENRC, then $HOME/.screenrc. The command line option -c takes precedence over the above user screenrc files.

Commands in these files are used to set options, bind functions to keys, and to automatically establish one or more windows at the beginning of your screen session. Commands are listed one per line, with empty lines being ignored. A command's arguments are separated by tabs or spaces, and may be surrounded by single or double quotes. A '#' turns the rest of the line into a comment, except in quotes. Unintelligible lines are warned about and ignored. Commands may contain references to environment variables. The syntax is the shell-like “$VAR ” or “${VAR}”. Note that this causes incompatibility with previous screen versions, as now the '$'-character has to be protected with '\' if no variable substitution shall be performed. A string in single-quotes is also protected from variable substitution.

Two configuration files are shipped as examples with your screen distribution: “etc/screenrc” and “etc/etcscreenrc”. They contain a number of useful examples for various commands.

Customization can also be done 'on-line'. To enter the command mode type 'C-a :'. Note that commands starting with “def” change default values, while others change current settings.

For a list of commands, see commands.